Associate Scientist/ Scientist/ Sr. Scientist, Pharmacometrics

Xyzagen (Zi*Za*Gen) is seeking a recent graduate scientist with good problem-solving skills and strengths in quantitative analysis. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of pharmacokinetic and/or pharmacodynamic analyses. Successful candidates will possess a passion for drug development and pharmacometrics and be an adaptable problem solver with an optimistic attitude.

Xyzagen is a contract research lab supporting pharmacokinetics, ADME and bioanalytical, pharmacology and nonGLP safety assessments in mice and rats. Xyzagen is also a drug development consultancy providing regulatory advice to clients in the nonclinical and clinical pharmacokinetic disciplines. Xyzagen has provided strategic advice to early NIH funded biotechs, small and mid-size pharma and venture capital firms. At Xyzagen, we accelerate medicines to patients by partnering with life science innovators. In the past 8 years, we have worked with over 100 different innovators worldwide and have helped in the approval of multiple new therapeutics by the FDA. Xyzagen also conducts its own research on Kv7 channel openers within the therapeutic areas of Neurology and Pain.

Our strong team of scientists and subject matter experts enable our clients to have:

• Cost effective and informed decision-making 
• Faster study start up for in vivo pharmacokinetic and safety assessment studies in rodents 
• Wide range of contract research services to regulatory advice regarding pharmacokinetics of a client’s molecule and therapeutic program.

Additionally, we are expanding our laboratory and office space from 5,000 to 11,000 sq ft to continue to provide a resource center for early innovators within the Life Science and Biotech communities.  

Job Responsibilities:
Our Scientist/ Sr. Scientist in Pharmacometrics is responsible for supporting client projects building computational models describing biological response to a molecule following dosing. Model complexity will depend on client needs, and applicants should have experience in one or more of the following forms of analysis: population PK, PK/PD, allometric scaling, PBPK and QSP modeling.

Candidates will have the ability to work on a variety of therapeutic indications from Ophthalmology through Respiratory, Pain and Neurology/Psychiatry with large and small molecules. The candidate will also be exposed to crafting regulatory documents, statistical analysis and study protocols for nonclinical studies and clinical trials. We are looking for the right individual that wants to:

• Expand their understanding of the pharmaceutical drug development process.
• Gain experiences applying pharmacometrics modeling concepts to a broad array of companies, molecular modalities, and therapeutic areas.
• Develop communication skills as a pharmacology consultant by contribution in business development and client management initiatives.
• Hands on pharmacometric modeling on client projects as a billable consultant.
• May lead/coordinate company initiatives (e.g. IT, methodology, efficiency, automation, quality).
• May act as the primary point of contact for clients and collaborate with the principal or senior consultant to grow business to match their interests.

Qualifications:

• BS, MS, PhD, PharmD in Pharmaceutical Sciences, Bioengineering, Pharmacology, Statistics, Applied Mathematics, Medicine, or a related field.
• Relevant years of industry experience will be considered alongside of educational degree. Academic research may be considered if deemed sufficiently aligned with the responsibilities of the role.
• Demonstrated understanding experience in some or all of the following: nonclinical and clinical pharmacology study design, pharmacometrics, modeling and simulation.
• Expertise in PK/PD modelling with strong quantitative skills applied to develop models with nonlinear behavior, mechanistic or semi-mechanistic components relating to mechanism of action and tailored to meet specific drug-development questions.
• Strong mathematical and statistical background and mathematical modeling quantitative skills applied to develop models with nonlinear behavior, mechanistic or semi-mechanistic components relating to mechanism of action and tailored to meet specific drug-development questions.
• Experience to Proficiency in PK/PD and statistical software (e.g., Phoenix, NLME, NONMEM, R, Prism).
• Excellent writing and verbal presentation skills to internal and external audiences. Experience with NIH or Department of Defense grants (nice to have).
• Strong communicator (written/oral) in client facing roles (presentation to clients and authoring of study reports).
• Exceptional time management and self-motivation.
• This position and compensation will range from Associate Scientist to Sr. Scientist depending on the individual’s qualifications. 

Physical Requirements:
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

• While performing the duties of this Job, the employee is frequently required to sit or stand for extended periods of time; use fine and gross motor hand skills in ensuring analytical equipment is maintained in operation.
• Must be able to speak and hear appropriately to communicate effectively with each associate or vendor.
• Specific vision abilities required by this job include close, distance and peripheral vision with the ability to adjust and focus.
• The employee on occasion will be required to lift and/or move up to 40 pounds.

Working Conditions:

• The noise level in the work environment is usually mild to moderate.

What We Offer:

• A competitive salary and meaningful equity compensation
• The compensation for this position will range from $65,000 to $115,000 depending on individual’s qualifications.
• A bright, collegial, highly motivated team working at the intersection of the most exciting area of science and technology
• Exceptional opportunities for learning and growth
• Company-paid holidays (closed between Christmas and New Year’s)
• Paid time off (2 weeks)
• Benefits (Medical, Dental and Vision)
• 401(k) plan + Safe Harbor Match + Profit Sharing + Defined Benefit retirement plan
• Flexible time off for personal business is not tracked
• Ability to work from home when possible
• Flexible schedule
• If relocating 50+ miles, potential for relocation stipend for relevant expenses

Xyzagen is a small company such that we are unable to sponsor visas for any candidate who is not eligible to work in the United States. Additionally, we cannot assist with the transfer of an employment visa from another company.