Senior Research Scientist, Myeloid Disease

Senior Research Scientist - Contract - Wilmington, DE

Drive the discovery of next‑generation cancer therapies by advancing myeloid disease research from target validation to preclinical insight.

Proclinical is working alongside a pharmaceutical company seeking to hire a Senior Research Scientist, Myeloid Disease, to join the team. This position will be responsible for performing in-vitro studies for cancer drug discovery programs. This includes developing relevant pre-clinical model systems to identify and validate novel therapeutic targets.

Primary Responsibilities:

The successful candidate is expected to work with minimal supervision in most molecular and cellular biology techniques and demonstrates an understanding of cancer biology. Experience with oncogenic signaling pathways and targeted therapies is an advantage. The candidate is expected to work with their supervisor to design and execute a research plan to answer critical questions about compounds and targets under evaluation.

Skills & Requirements:

• Bachelor's degree in molecular biology, stem cell biology, or a related discipline with a minimum of five (5) years of relevant industry experience, or Master's in a related field with a minimum of (2) years of relevant industry experience, or a Ph.D. in a related field with at least three (3) years of postdoctoral or equivalent research experience.
• Demonstrated track record of developing, optimizing, and executing functional cellular assays to assess proliferation, differentiation, and apoptosis in biologically relevant model systems.
• Strong theoretical grounding combined with hands-on expertise in assays utilizing primary stem cells; experience in hematopoietic stem cell biology or myeloid malignancies (MPN, MDS or AML) is strongly preferred.
• Proven technical proficiency in core molecular and cellular biology methodologies, including ELISA, MSD-based assays, Western blotting, multicolor flow cytometry, and CRISPR/Cas9 gene-editing platforms; experience with CRISPR-based screening approaches is a plus.
• Experience leveraging advanced 3D tissue or organoid models, to recapitulate disease biology in physiologically relevant contexts.

The Senior Research Scientist's responsibilities will be:

• Leverage chemical and genetic modalities to design, execute, and interpret experiments with a high degree of scientific independence and accountability.
• Establish and deploy disease-relevant preclinical models to interrogate target biology and address complex mechanistic hypotheses.
• Contribute to small- and large-molecule screening efforts across exploratory research and lead optimization programs, ensuring data quality and translational relevance.
• Collaborate with other functional groups within drug discovery to achieve shared goals.
• Flexibility to acquire additional competencies and skillsets as needed.
• Excellent verbal and written communication skills, specifically in conveying complex and technical information into a clear and understandable format to both internal and external audiences.

If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at [email protected]

If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.

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