Senior Clinical Project Manager - Inflammation/ Phase 2b (Sponsor Dedicated - Remote; Preference for Hybrid Foster City, CA )

Senior Clinical Project Manager – Inflammation/ Phase 2b (Sponsor Dedicated - Remote; Preference for Hybrid Foster City, CA )

Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.

Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.

Discover what your 25,000 future colleagues already know:

Why Syneos Health
• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.

Job Responsibilities

Senior Clinical Project Manager – Inflammation / Phase 2b

Sponsor Dedicated | Remote (U.S.-Based)

Preference for Hybrid Foster City, CA-Based Candidates

Are you a senior clinical operations professional who knows how to independently lead complex global clinical trials from start-up through closeout — while still staying deeply connected to the operational details that drive execution success?

This is a highly visible opportunity supporting large-scale global Phase 2b inflammation programs within a sponsor-dedicated environment. The ideal candidate brings both strategic global trial leadership and a hands-on operational mindset — someone who can confidently lead international cross-functional teams, oversee global vendors and CROs, and still comfortably work “in the weeds” to proactively solve problems, remove roadblocks, and keep studies moving forward.

This role is best suited for a Senior Clinical Project Manager who thrives in fast-paced, high-accountability environments where timelines move quickly, priorities shift often, and strong execution is critical. You will play a central role in driving operational excellence across complex global studies spanning multiple regions and stakeholders.

While remote/home-based candidates may be considered, priority will be given to candidates located in or near Foster City, California, with the ability to work onsite 2–3 days per week.

WHAT MAKES THIS OPPORTUNITY DIFFERENT:

• Opportunity to lead highly visible, large-scale global Phase 2b clinical programs with significant strategic and operational impact

• Exposure to complex international trial execution across North America, Europe, APAC, Japan, and China

• Significant ownership and autonomy with the expectation to independently drive studies from start-up through closeout

• Ability to influence operational strategy while remaining deeply involved in day-to-day execution

• Collaborative sponsor-dedicated environment with engaged leadership that values partnership, communication, and professional growth

• Work alongside experienced global clinical operations professionals in a highly supportive and team-oriented culture

• Fast-paced environment that values accountability, urgency, collaboration, and executional excellence

• Excellent opportunity for senior Clinical Project Managers seeking broader global responsibility, increased visibility, and continued advancement within clinical operations leadership

WHAT YOU WILL OWN

Global Clinical Trial Leadership & Execution

• Independently lead complex global clinical trials from study start-up through database lock and closeout

• Drive operational execution across multiple international regions while maintaining alignment to global study strategy and timelines

• Maintain deep operational oversight across all aspects of study execution — this is not a “high-level only” oversight role

• Operate effectively both strategically and tactically, balancing big-picture program leadership with hands-on operational involvement

• Proactively identify global operational risks, regional challenges, and study execution issues while driving resolution plans forward

• Ensure study deliverables, milestones, and timelines remain on track within fast-paced development environments

• Lead global study execution efforts across cross-functional stakeholders, vendors, CROs, and regional teams

Global Vendor & CRO Oversight

• Provide strong oversight and accountability management for global CROs and external vendors

• Lead vendor governance discussions, escalation management, and performance oversight activities

• Drive operational follow-through and execution accountability across external partners

• Contribute to vendor strategy, resourcing discussions, and operational planning activities

• Navigate complex global vendor relationships across multiple regions and time zones

Cross-Functional Global Leadership

• Lead large, matrixed global cross-functional teams within highly collaborative clinical development environments

• Facilitate effective meetings with clear agendas, decision-making, accountability, and follow-up

• Build strong partnerships across Clinical Operations, Data Management, Regulatory, Safety, Medical, and external stakeholders

• Communicate confidently with senior leadership while effectively managing competing priorities and stakeholder expectations

• Mentor junior team members and contribute to a collaborative, solutions-oriented team culture

Study Operations & Clinical Program Management

• Oversee development and review of key study documents including protocols, informed consents, monitoring plans, investigator brochures, and clinical study reports

• Support global study planning, forecasting, budget management, and resource coordination

• Review operational metrics, study data listings, enrollment trends, and study performance indicators

• Ensure alignment across regional operational requirements and global study objectives

• Contribute to process improvement initiatives, SOP development, and operational best practices

WHO YOU ARE

Required Qualifications

• Significant Clinical Operations and global clinical trial management experience within CRO, biotech, or pharmaceutical environments

• Proven success independently leading complex global clinical trials from start-up through closeout

• Strong experience managing large-scale international studies across multiple global regions

• Demonstrated expertise leading global cross-functional teams and managing complex stakeholder environments

• Strong vendor oversight and CRO management experience with the ability to drive accountability and execution

• Ability to operate effectively at both strategic and tactical levels, including deep involvement in operational study details

• Excellent organizational, communication, risk management, and problem-solving skills

• Proven ability to manage competing priorities and maintain executional excellence in fast-paced clinical development environments

• Strong leadership presence with high emotional intelligence and the ability to build credibility across teams and leadership levels

• Experience navigating complex global operational challenges, timelines, and regional considerations

Preferred Qualifications

• Phase 2b global study leadership experience strongly preferred

• Inflammation therapeutic area experience preferred

• Experience managing studies across APAC, Japan, and China regions

• Experience within sponsor-dedicated or embedded sponsor models

• Stable career progression demonstrating increasing ownership, operational leadership, and global study complexity

• Ability to thrive in highly collaborative, high-visibility, and high-accountability environments

TEAM CULTURE:

This team values collaboration, transparency, accountability, and execution. Leadership is highly engaged, approachable, and supportive, while also maintaining high expectations around ownership and operational excellence. The environment is fast-moving and highly interactive, making it an ideal fit for professionals who enjoy being actively involved in solving problems, driving execution, and partnering closely with teams across the globe.

The strongest candidates for this role are individuals who naturally take initiative, communicate proactively, stay calm under pressure, and are comfortable leading highly complex studies while remaining deeply connected to operational execution details.

If you are looking for an opportunity to lead globally visible inflammation programs, drive complex international clinical trial execution from start to finish, and make a meaningful operational impact within a collaborative sponsor environment, this is the kind of role that elevates careers!

At  Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.

Salary Range:

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.