Research Scientist/Sr. Research Scientist, Purification Process Sciences

Overview:

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)
The Senior Purification Scientist supports protein purification process development and optimization primarily for novel therapeutic monoclonal antibody products including bispecifics throughout all stages of clinical trials.

Essential Functions of the Job (Key responsibilities)

• Conduct routine protein purification to support formulation team’s material needs and cell culture development
• Conduct high-throughput protein purification to support cell line development
• Conduct purification process development, optimization, and scale-up
• Conduct routine analyses of in-process samples using relevant product purity and process impurity analytical tools
• Prepare buffers and solutions needed for laboratory work
• Manage laboratory supplies and instrument maintenance
• Write routine electronic laboratory notebook and development reports
• Participate and present updates in routine group meetings
• Other responsibilities as assigned

Qualifications (Minimal acceptable level of education, work experience, and competency)

• BS or MS. degree in biochemistry, bioengineering, biology, chemistry or related fields, preferably with at least 3 years of relevant industry experiences
• Good knowledge of protein chemistry and bioprocessing
• Good knowledge and hands-on experience in various types of column/membrane chromatography (affinity, size exclusion, ion exchanges, multi-mode) and filtration technology (depth filtration, tangential flow filtration, and nanofiltration)
• Experience in using AKTA line of purification instruments
• Experience in using ultrafiltration/diafiltration instrument for buffer exchange, product concentration, and formulation
• Experience in protein analysis such as HPLC, ELISA, etc.
• Good verbal and written communication skills
• Organized, cooperative, independent, meticulous
• Experience in protein purification process development, Design of Experiment methodology, and high-throughput protein purification platform are desirable but not required.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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