Senior Data Engineer - (Durham NC or Menlo Park, CA) - #4571

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Data Engineer will partner with scientists and statisticians to support efficient and accurate capture, transfer, and aggregation of sample information and analysis results through GRAIL’s analysis systems. As such, the Data Engineer will become proficient in GRAIL’s system architecture, including primarily GRAIL’s LIMS for laboratory data; Electronic Data Capture (EDC) for clinical study data; the Bioinformatics Pipeline for sequence analysis and cancer classification data; and TidyData, the system that aggregates, packages, and serves datasets created from LIMS, EDC, and Pipeline outputs.

The Data Engineer will also collaborate with software engineers and scientists to develop requirements and produce analysis-ready datasets for clinical research and product development. The Data Engineer will develop code and procedures to support dataset generation, perform QC, and troubleshoot issues that arise during dataset generation. The Data Engineer will also collect requirements, develop prototypes, and collaborate on production implementations of new reporting, data visualization, and statistical analysis features as needed.

The Data Engineer will learn analysis requirements by reading laboratory protocols, Statistical Analysis Plans, and other analysis planning documents and meeting with scientists, biostatisticians, and other stakeholders. They will demonstrate a consistent commitment to delivering on team goals with a sense of shared urgency.

This is a hybrid role based in either Menlo Park, CA (moving to Sunnyvale, CA in Fall 2026) or Durham, NC . Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site.

Responsibilities

• Independently execute on sample selection strategies for studies according to analysis requirements
• Collect user requirements, develop and automate custom reporting features
• Promote self-service data platform adoption through training, process improvements, and infrastructure updates
• Reconcile multi-dimensional data across databases and systems to ensure data integrity
• Develop and improve tools to enable dataset creation and update, data QC and reconciliation, data transfer, and sample selection

These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion

Required Qualifications

• BS with 5+ years of related experience or MS with 3+ years of related experience in a computatonal or scientific field (life science, computer science, engineering, mathematics, statistics, bioinformatics, etc.)
• Strong proficiency in R or Python programming
• Comfort working across the full data stack — from ingestion and transformation to orchestration and visualization
• Excellent interpersonal communication (written and verbal) and organizational skills
• Team player with demonstrated success in a cross-functional environment

Preferred Qualifications

• Experience using a system-level programming language like Go, Java or C++
• Understands basic concepts of molecular biology
• Familiarity with AI-assisted coding or data workflows
• Experience with Amazon Web Services
• Proficiency in SQL development and data warehousing concepts

Expected full time annual base pay scale for this position is $132K-$175K. Actual base pay will consider skills, experience and location.

This role may be eligible for other forms of compensation, including an annual bonus and/or incentives, subject to the terms of the applicable plans and Company discretion. This range reflects a good-faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package, offered in accordance with our applicable plans and policies. This package currently includes flexible time-off or vacation; a 401(k) retirement plan with employer match; medical, dental, and vision coverage; and carefully selected mindfulness programs.

GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, , or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!